PERK Modulators

Featured Inhibitors
Inhibitors (5)
Modulators (3)
Activators (3)

Cat.No.	Product Name	Information	Product Use Citations
S8304	Azoramide	Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.	Nat Commun, 2025, 16(1):6247 PeerJ, 2024, 12:e16844 J Adv Res, 2022, S2090-1232(22)00149-7
S7437	Sal003	Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.	Front Pharmacol, 2023, 14:1095307 bioRxiv, 2023, 2023.05.19.540602
S2923	Salubrinal	Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.	Cell Discov, 2025, 11(1):80 Cell Metab, 2025, 37(8):1715-1731.e11 EMBO J, 2025, 44(4):1107-1130

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S8304

Azoramide

Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.

Nat Commun, 2025, 16(1):6247

PeerJ, 2024, 12:e16844

J Adv Res, 2022, S2090-1232(22)00149-7

S7437

Sal003

Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.

Front Pharmacol, 2023, 14:1095307

bioRxiv, 2023, 2023.05.19.540602

S2923

Salubrinal

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

Cell Discov, 2025, 11(1):80

Cell Metab, 2025, 37(8):1715-1731.e11

EMBO J, 2025, 44(4):1107-1130