PERK Activators

Featured Inhibitors
Inhibitors (5)
Modulators (3)
Activators (3)

Cat.No.	Product Name	Information	Product Use Citations
S0006	BTdCPU	BTdCPU is a potent activator of heme regulated inhibitor kinase (HRI), one of eukaryotic translation initiation factor 2α kinases (eIF2α-kinases).	EMBO Rep, 2024, 25(10):4488-4514 EMBO Reports, 2024, 4488-4514 Frontiers in Cell and Developmental Biology, 2021, 675486
E1030	CCT020312	CCT020312 is a selective PERK (EIF2AK3) activator with an EC50 of 5.1 μM. This compound can be used for the selective activation of EIF2A-mediated translation control.	Int J Mol Sci, 2023, 24(21)15561 International Journal of Molecular Sciences, 2023, 15561 Int J Mol Med, 2023, 52(1)56
S6952	MK-28	MK-28 is a potent and selective activator of PERK. This compound exhibits an IC50 ~3-fold higher than CCT020312 in rescuing mutant huntingtin protein (mHtt)-expressing striatal neurons from apoptosis. It exhibits remarkable pharmacokinetic properties and high BBB penetration in mice.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S0006

BTdCPU

BTdCPU is a potent activator of heme regulated inhibitor kinase (HRI), one of eukaryotic translation initiation factor 2α kinases (eIF2α-kinases).

EMBO Rep, 2024, 25(10):4488-4514

EMBO Reports, 2024, 4488-4514

Frontiers in Cell and Developmental Biology, 2021, 675486

E1030

CCT020312

CCT020312 is a selective PERK (EIF2AK3) activator with an EC50 of 5.1 μM. This compound can be used for the selective activation of EIF2A-mediated translation control.

Int J Mol Sci, 2023, 24(21)15561

International Journal of Molecular Sciences, 2023, 15561

Int J Mol Med, 2023, 52(1)56

S6952

MK-28

MK-28 is a potent and selective activator of PERK. This compound exhibits an IC50 ~3-fold higher than CCT020312 in rescuing mutant huntingtin protein (mHtt)-expressing striatal neurons from apoptosis. It exhibits remarkable pharmacokinetic properties and high BBB penetration in mice.