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Other MAPK Related Inhibitors

MEK p38 MAPK Raf JNK ERK S6 Kinase MNK TOPK Mixed Lineage Kinase TAK1
Cat.No. Product Name Information Product Use Citations Product Validations
S6930 MK2 Inhibitor III MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM.
E1657 Gamcemetinib (CC-99677) Gamcemetinib (CC-99677,BMS-986371) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) (MAPKAPK2 (MK2)) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM).
E2407 MK2-IN-1 hydrochloride MK2-IN-1 hydrochloride is a potent and selective MAPKAP-K2 (MK2) inhibitor with IC50 of 0.11 μM with a non-ATP competitive binding mode.
E1271 Zunsemetinib Zunsemetinib(ATI-450, CDD-450) is a selective inhibitor of p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) that mediates inflammatory responses. It reduces inflammation in cryopyrinopathy, alleviates arthritis, and potentially prevents tachyphylaxis.
S8224 PF-3644022

PF-3644022 is a potent freely reversible ATP-competitive inhibitor of MAPKAPK2 (MK2) with an Ki of 3 nM. This compound also potently inhibits TNFα production with an IC50 of 160 nM.
iScience, 2024, 27(4):109339