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TOPK Inhibitors

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Cat.No. Product Name Information Product Use Citations Product Validations
S7652 OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
Exp Mol Med, 2022, 54(7):999-1010
Mol Oncol, 2021, 15(12):3721-3737
Oncogenesis, 2021, 10(1):9
S7648 OTS964 OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. This compound is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. This chemical treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.
Mol Oncol, 2025, 10.1002/1878-0261.70143
Sci Adv, 2025, 11(4):eadq2395
Nucleic Acids Res, 2023, gkad001
S6882 HI-TOPK-032 HI-TOPK-032 is a potent and specific inhibitor of TOPK. This compound also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
S7652 OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
Exp Mol Med, 2022, 54(7):999-1010
Mol Oncol, 2021, 15(12):3721-3737
Oncogenesis, 2021, 10(1):9
S7648 OTS964 OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. This compound is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. This chemical treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.
Mol Oncol, 2025, 10.1002/1878-0261.70143
Sci Adv, 2025, 11(4):eadq2395
Nucleic Acids Res, 2023, gkad001
S6882 HI-TOPK-032 HI-TOPK-032 is a potent and specific inhibitor of TOPK. This compound also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.