TOPK

Other MAPK Related Inhibitors

MEK p38 MAPK Raf JNK ERK S6 Kinase MNK Mixed Lineage Kinase TAK1 KLF

Cat.No.	Product Name	Information	Product Use Citations
S7652	OTS514 hydrochloride	OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.	Oral Diseases, 2024 Mar, 30(2):223-234 Frontiers in Pharmacology, 2022 Jan 18, 12:772926 Exp Mol Med, 2022, 54(7):999-1010
S7648	OTS964	OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. This compound is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. This chemical treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.	Molecular Oncology, 2025, nan Mol Oncol, 2025, 10.1002/1878-0261.70143 Sci Adv, 2025, 11(4):eadq2395
S6882	HI-TOPK-032	HI-TOPK-032 is a potent and specific inhibitor of TOPK. This compound also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7652

OTS514 hydrochloride

OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.

Oral Diseases, 2024 Mar, 30(2):223-234

Frontiers in Pharmacology, 2022 Jan 18, 12:772926

Exp Mol Med, 2022, 54(7):999-1010

S7648

OTS964

OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. This compound is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. This chemical treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.

Molecular Oncology, 2025, nan

Mol Oncol, 2025, 10.1002/1878-0261.70143

Sci Adv, 2025, 11(4):eadq2395

S6882

HI-TOPK-032

HI-TOPK-032 is a potent and specific inhibitor of TOPK. This compound also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.