| S7811 |
MHY1485
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MHY1485 is a potent, and cell-permeable mTOR activator, and this compound also potently inhibits autophagy.
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Research (Wash D C), 2025, 8:1002
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Front Immunol, 2025, 16:1643676
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Biol Res, 2025, 58(1):67
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| S8317 |
3BDO
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3BDO, a butyrolactone derivative, could target FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs. This compound inhibits oxLDL-induced apoptosis.
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NPJ Parkinsons Dis, 2024, 10(1):52
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Adv Sci (Weinh), 2023, 10(13):e2205436
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Research Square, 2023, 10.21203/rs.3.rs-3629594/v1
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| S2396 |
Salidroside
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Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. This compound is a prolyl endopeptidase inhibitor. It alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. This chemical protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
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PLoS One, 2024, 19(7):e0306926
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Mol Med Rep, 2023, 27(2)37
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Research Square, 2023, 10.21203/rs.3.rs-3696850/v1
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| S3753 |
L-Leucine
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Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
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