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GluR Agonists

Cat.No. Product Name Information Product Use Citations Product Validations
S6001 pomaglumetad (LY404039) Pomaglumetad (LY404039) is a potent agonist of recombinant human mGlu2/mGlu3 receptors with Ki of 149 nM/92 nM, and it shows >100-fold selectivity over ionotropic glutamate receptors, glutamate transporters, and other receptors. This compound has reached Phase 3.
Schizophr Bull, 2021, sbab047
Neuropsychopharmacology, 2020, 10.1038/s41386-020-0764-2
Sci Rep, 2019, 9(1):14247
Verified customer review of pomaglumetad (LY404039)
S6266 (S)-Glutamic acid (S)-Glutamic acid (L-Glutamic acid) is an endogenous, non-selective glutamate receptor agonist.
Cell Biosci, 2024, 14(1):135
Cancer Sci, 2022, 113-6:1955-1967
CHEM ENG J, 2021, 10.1016/j.cej.2021.130083
S5137 O-Phospho-L-serine O-Phospho-L-serine (Dexfosfoserine), a molecule that mimics the phosphatidylserine head group and partially blocks microglial phagocytosis of apoptotic cells, is a specific group III metabotropic glutamate receptor (mGluR) agonist.
Int J Mol Sci, 2022, 23(18)10551
Front Physiol, 2022, 13:1008073
S4721 L-Glutamic acid monosodium salt L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. This compound acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). It shows a direct activating effect on the release of DA from dopaminergic terminals.
Heliyon, 2024, 10(1):e23945
Acta Biomater, 2022, 152:255-272
S2690 ADX-47273 ADX47273 (BA 94673139) is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.
J Biol Chem, 2014, 289(41):28460-77
S2795 VU 0357121 VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes.
Sci Rep, 2025, 15(1):17364
S8035 VU 0364439 VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
Antioxidants (Basel), 2018, 10.3390/antiox7110150
E1400 Kainic acid Kainic acid (algakaininso) is a potent neuroexcitatory compound derived from the red alga Digenea simplex, which acts as an agonist for AMPA/kainate-type ionotropic glutamate receptors. It induces excitotoxicity by promoting excessive Ca²⁺ influx, leading to oxidative stress, mitochondrial dysfunction, and selective neuronal death.
E1257 (R,S)-3,5-DHPG Hydrochloride (R,S)-3,5-DHPG hydrochloride (DHPG, Dihydroxy phenylglycine) is a salt of free amino acid dihydroxy phenylglycine (DHPG) which acts as a selective and potent agonist of group I metabotropic glutamate receptors (mGluR) (mGluR 1 and mGluR 5).
S0165 Ampalex (CX-516) Ampalex (CX-516, Ampakine CX 516, BDP-12, SPD 420) is a positive allosteric modulator of AMPA receptor and exhibits potential for the treatment of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
S2862 VU 0364770 VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes.
S2892 VU 0361737 VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS.
S6803 1-BCP 1-BCP (Piperonylic acid piperidide) is a memory-enhancing agent that enhances AMPA-induced currents.
S5222 Coluracetam Coluracetam (BCI-540, MKC-231) is a nootropic belonging to the racetam family of drugs with cognitive enhancing and neuroprotective effects.
S3070 Piracetam Piracetam (UCB 6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.