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GluR Modulators

Cat.No. Product Name Information Product Use Citations Product Validations
S6804 CX546 CX546, a prototypical ampakine agent, is a selective positive AMPA receptor modulator.
E5810 Ro 67-7476 Ro 67‑7476 is a potent positive allosteric modulator (PAM) of mGluR1, enhancing glutamate‑evoked responses in calcium mobilization assays with an EC50 of 60.1 nM. It also exhibits intrinsic agonist activity, inducing ERK1/2 phosphorylation in the absence of exogenous glutamate with an EC50 of 163.3 nM.
S1970 VU-29 VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor, with EC50 of 9 nM and Ki=244 nM for rat mGluR5, which is selective for mGluR5 relative to other mGluR subtypes.
S6618 JNJ-42153605 JNJ-42153605 is a potent and selective mGlu2 receptor positive allosteric modulator with an EC50 of 17 nM.
S2434 IDRA-21 IDRA-21 is a partial allosteric modulator of AMPA receptor desensitization. This compound is a potent cognition-enhancing drug virtually devoid of neurotoxic liability.
E5887New Osavampator Osavampator (TAK-653, NBI-1065845) is a positive allosteric modulator (PAM) of AMPA receptors. It enhances glutamate-induced calcium influx in CHO cells expressing human AMPA receptors with an EC50 of 3.3 µM and potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons with an EC50 of 4.4 µM.