Haspin Kinase

Other Cell Cycle Related Inhibitors

CDK ROCK Wee1 Aurora Kinase Chk PLK APC MPS1 Rho Myc

Cat.No.	Product Name	Information	Product Use Citations
S3406	LDN-192960	LDN-192960 (Compd 1) is a potent inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50 of 10 nM and 48 nM, respectively.	Colloids Surf B Biointerfaces, 2022, 209(Pt 1):112182
E1132	CHR-6494	CHR-6494 is a potent inhibitor of haspin, with an IC50 of 2 nM, inhibits histone H3T3 phosphorylation, and can be used in the research of cancer.
S2198	SGI-1776 free base	SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.	Cell Death Dis, 2024, 15(9):644 Mar Drugs, 2024, 22(10)444 Mol Cancer, 2023, 22(1):64

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S3406

LDN-192960

LDN-192960 (Compd 1) is a potent inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50 of 10 nM and 48 nM, respectively.

Colloids Surf B Biointerfaces, 2022, 209(Pt 1):112182

E1132

CHR-6494

CHR-6494 is a potent inhibitor of haspin, with an IC50 of 2 nM, inhibits histone H3T3 phosphorylation, and can be used in the research of cancer.

S2198

SGI-1776 free base

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.

Cell Death Dis, 2024, 15(9):644

Mar Drugs, 2024, 22(10)444

Mol Cancer, 2023, 22(1):64

Verified customer review of SGI-1776 free base