| S0436 |
Pleconaril
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Pleconaril (APO-P001, Picovir, VP 63843, WIN 63843) is a capsid inhibitor used previously to treat enterovirus infections. This compound is effective in inhibiting replication with IC50 of < 0.050 μM.
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| S5183 |
PD 169316
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PD 169316 is a potent, selective and cell-permeable p38 MAP kinase inhibitor with IC50 of 89 nM. PD169316 abrogates signaling initiated by both TGFbeta and Activin A. PD169316 shows antiviral activity against Enterovirus71.
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Journal of Dairy Science, 2026, 795-809
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J Dairy Sci, 2025, S0022-0302(25)00833-1
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PLoS One, 2021, 16(5):e0252541
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| S9018 |
Luteoloside
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Luteoloside (Cynaroside, Luteolin 7-β-D-Glucopyranoside) is a member of the flavonoids family that exhibits several bioactivities including anti-microbial and anti-cancer activities. It is an inhibitor of 3C Protease of Enterovirus 71 with an IC50 value of 0.36 mM.
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Histol Histopathol, 2025, 18922
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Pharmaceuticals (Basel), 2023, 16(4)548
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| E1741New |
Rupintrivir
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Rupintrivir (AG7088) is an irreversible, selective, and potent inhibitor of human rhinovirus (HRV) 3C protease. In H1-HeLa and MRC-5 cell protection assays, it demonstrates antiviral activity against 48 HRV serotypes, exhibiting a mean EC50 of 0.023 μM. Additionally, rupintrivir exhibits immunomodulatory properties.
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