Home Metabolism Drug Metabolite

Drug Metabolite Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2205 DesMethyl Erlotinib (OSI-420) HCl DesMethyl Erlotinib (OSI-420) HCl is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
Drug Metab Dispos, 2025, 53(5):100069
J Pharm Biomed Anal, 2023, 236:115716
Front Oncol, 2022, 12:939118
Verified customer review of DesMethyl Erlotinib (OSI-420) HCl
S1501 Mycophenolate mofetil Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. This compound induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells.
Cell Metab, 2025, S1550-4131(25)00482-6
Cancers, 2025, 3389
Haematologica, 2024, 109(12):3989-4006
Verified customer review of Mycophenolate mofetil
S3698 Nortriptyline hydrochloride Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.
Frontiers in Bioinformatics, September 14, 2021, 710591
EMBO Molecular Medicine, December 23, 2025, 433-461
EMBO Molecular Medicine, December 23, 2025, Epub ahead of print
E4607 Oseltamivir acid Oseltamivir acid(GS 4071,Ro 64-0802,Oseltamivir carboxylate), a metabolite of the antiviral compound oseltamivir, acts as a competitive inhibitor of influenza neuraminidases A and influenza neuraminidases B with IC50 of 0.1 to 4.9 nM respectively, thereby preventing virus budding and release.
E0680 Deslanoside Deslanoside(Desacetyllanatoside C) is a cardenolide glycoside, has the effects of anti-arrhythmia and cardiotonic, also is used as an EC 3.6.3.9 (Na+/K+-transporting ATPase) inhibitor. 
S6438 Ufiprazole Ufiprazole (Omeprazole sulfide) is an intermediate used in the production of the gastric proton pump inhibitors omeprazole and esomeprazole.
S4509 4-Aminoantipyrine 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
S0225 IMR-1A IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. This compound exhibits anti-tumor activity.