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CD markers Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
E1305 RBN013209 RBN013209 is a potent inhibitor of CD38 with an IC50 of 0.01-0.1 μM for human CD38. It can be used for the research of cancer.
E5853New SMS121 SMS121 is a potent inhibitor of CD36 with a Kd value of 5.57 µM. It impairs fatty acid uptake, as well as the viability and proliferation of acute myeloid leukemia (AML) cells, indicating its potential as a future therapeutic agent against AML.
S2632 BMS-378806 BMS-378806 (BMS 806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.
Commun Biol, 2025, 8(1):442
Commun Biol, 2023, 6(1):535
J Virol, 2021, 95(24):e0052921
S6239 PMX-53 PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. This compound is also an agonist of Mas-related gene 2 (MrgX2).
Redox Biol, 2025, 86:103802
Biomolecules, 2025, 15(8)1106
Thromb J, 2022, 20(1):24
S0474 Avacopan (CCX168) Avacopan is an orally administered and selective C5a receptor (C5aR) antagonist.
Br J Cancer, 2025, 10.1038/s41416-025-03185-0
Nat Commun, 2024, 15(1):6519
Cell Death Dis, 2022, 13(5):500
P1208 PMX 205 acetate

PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.
Ecotoxicol Environ Saf, 2025, 289:117627
Int Immunopharmacol, 2023, 125(Pt B):111112
S7487 YYA-021 YYA-021 is a CD4-mimic HIV entry inhibitor, competitively inhibiting the interaction between gp120 and CD4.
S6347 5'-N-Ethylcarboxamidoadenosine (NECA) 5'-N-Ethylcarboxamidoadenosine (NECA, 5'-(N-Ethylcarboxamido)adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. It acts via multiple mechanisms including: reducing diabetes-induced oxidative stress, inhibiting gene expression of IL-18, TNF-α and ICAM-1 (intercellular adhesion molecule 1 (CD54)), and blocking activation of the JNK-MAPK pathway.