Home Metabolism Carbonic Anhydrase

Carbonic Anhydrase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2866 U-104 (SLC-0111) U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.
Eur Thyroid J, 2025, 14(3)e250022
European Thyroid Journal, 2025, e250022
Nat Immunol, 2023, 24(11):1867-1878
Verified customer review of U-104 (SLC-0111)
S1438 Topiramate Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
Anticancer Research, February 2021, 687-697
EMBO Molecular Medicine, December 23, 2025, 433-461
J Headache Pain, 2025, 26(1):182
S4506 Acetazolamide Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
Commun Biol, 2025, 8(1):28
Eur Thyroid J, 2025, 14(3)e250022
European Thyroid Journal, 2025, e250022
S3178 Brinzolamide Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.
Cell Rep, 2025, 44(4):115450
Commun Biol, 2025, 8(1):28
bioRxiv, 2024, 2024.03.13.584872
S9742 Indisulam (E7070) Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.
Nat Commun, 2025, 16(1):9754
Oncogenesis, 2024, 13(1):25
Cancer Cell, 2022, S1535-6108(22)00312-9
S1375 Dorzolamide HCl Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.
Neuro-Oncology, October 01, 2021, 1709-1722
Neuro Oncol, 2021, noab156
Neuro-Oncology, 2021, 1709-1722
S1736 Methocarbamol Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
Cancer Research Communications, 2025, 906-920
Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433
bioRxiv, 2020, nan
S4039 Methazolamide Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
The American Journal of Pathology, November 2025, 2176-2196
The American Journal of Pathology, June 19 2025, 2176-2196
Diabetes, April 01 2022, 795-811
S3697 Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
Theranostics, 2024, 593-607
ETD, 2020, N/A
S4725 Benzenesulfonamide Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.
Br J Pharmacol, 2016, 173(6):1018-32
S2603 Tioxolone Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S2177 Dichlorphenamide Dichlorphenamide (Diclofenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S3647 Mafenide Acetate Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
E6058 Acetazolamide sodium Acetazolamide sodium is an inhibitor of carbonic anhydrase (CA) IX with an IC50 of 30 nM for hCA IX and also inhibits hCA II with an IC50 of 13 nM. It possesses diuretic, antihypertensive, and anti-gonococcal properties.
S4998 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of Carbonic Anhydrase IX (CAIX) / Carbonic Anhydrase 9 (CA9).