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CaMK Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S7423 KN-93 Phosphate KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. KN-93 attenuates CaMKII-induced autophagy.This product is not soluble in saline. Please do not dissolve it in saline for administration.
Stem Cell Res Ther, 2025, 16(1):208
bioRxiv, 2025, 2025.03.20.644192
Eye Vis (Lond), 2024, 11(1):37
Verified customer review of KN-93 Phosphate
S6787 KN-93 KN-93 is a cell-permeable, reversible and competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK-II) with Ki of 2.58 μM at rabbit myocardial CaM kinase activity.
Acta Neuropathol Commun, 2025, 13(1):70
Int J Mol Med, 2025, 56(5)196
Nat Commun, 2024, 15(1):840
S8274 STO-609 STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. This compound inhibits AMPKK activity and inhibits autophagy.
Redox Rep, 2025, 30(1):2447721
PLoS One, 2025, 20(8):e0330282
Cell Genom, 2025, 5(3):100782
S7422 KN-62 KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM). It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of this compound for CaMK V is 0.8 μM.
J Extracell Vesicles, 2025, 14(8):e70149
Cell Rep, 2025, 44(6):115839
Redox Biol, 2024, 75:103249
Verified customer review of KN-62
S7436 NH125 NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
Acta Pharmacol Sin, 2018, 10.1038/s41401-018-0165-9
Drug Des Devel Ther, 2018, Drug Des Devel Ther
BMC Cancer, 2016, 16(1):813
Verified customer review of NH125
E5833New KN-93 hydrochloride KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.
S1421 Staurosporine (STS) Staurosporine (STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. This compound also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
Cell Metab, 2025, S1550-4131(25)00149-4
Mol Cell, 2025, 85(19):3711-3728.e11
EMBO J, 2025, 10.1038/s44318-025-00526-w
Verified customer review of Staurosporine (STS)
S7188 CID755673 CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.
World Allergy Organ J, 2025, 18(8):101089
J Thromb Haemost, 2024, S1538-7836(24)00618-4
Nat Commun, 2023, 14(1):3543
S2642 1-Naphthyl PP1(1-NA-PP1) 1-Naphthyl PP1 (1-NA-PP1) is a highly selective and potent pan-PKD inhibitor with IC50 values of 154.6 nM, 133.4 nM, and 109.4 nM for PKD1, PKD2, and PKD3, respectively. It also acts as a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl, with IC50 values of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM, and 22 μM for v-Src, c-Fyn, c-Abl, CDK2, and CAMK II, respectively.
Cancer Gene Ther, 2025, 10.1038/s41417-025-00874-z
Cell Rep, 2024, 43(1):113617
S6214 H-1152 dihydrochloride H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
Cell Rep Med, 2025, 6(8):102297
S6383 1-NM-PP1 1-NM-PP1 (PP1 Analog II, 1NM-PP1, analogue 9) is a potent inhibitor of Src family kinases with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. This compound also inhibits CDK2-as1, CAMKII-as1 and c-Abl-as2 with IC50 of 5.0 nM, 8.0 nM and 120 nM, respectively.
J Cell Biol, 2024, 223(11)e202403165
E2202 1-Naphthyl PP1 hydrochloride 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of Src family kinases, inhibits v-Src, c-Fyn, c-Abl, CDK2 and CAMKII with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively.