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CaMK Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2642 1-Naphthyl PP1(1-NA-PP1) 1-Naphthyl PP1 (1-NA-PP1) is a highly selective and potent pan-PKD inhibitor with IC50 values of 154.6 nM, 133.4 nM, and 109.4 nM for PKD1, PKD2, and PKD3, respectively. It also acts as a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl, with IC50 values of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM, and 22 μM for v-Src, c-Fyn, c-Abl, CDK2, and CAMK II, respectively.
Cancer Gene Ther, 2025, 10.1038/s41417-025-00874-z
Cell Rep, 2024, 43(1):113617
S3609 Berbamine dihydrochloride Berbamine (BA, BBM) dihydrochloride, a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA, BBM) dihydrochloride induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).
iScience, 2024, 27(10):110862
Eur J Pharmacol, 2024, S0014-2999(24)00322-4
S6214 H-1152 dihydrochloride H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
Cell Rep Med, 2025, 6(8):102297
S6383 1-NM-PP1 1-NM-PP1 (PP1 Analog II, 1NM-PP1, analogue 9) is a potent inhibitor of Src family kinases with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. This compound also inhibits CDK2-as1, CAMKII-as1 and c-Abl-as2 with IC50 of 5.0 nM, 8.0 nM and 120 nM, respectively.
J Cell Biol, 2024, 223(11)e202403165
E2202 1-Naphthyl PP1 hydrochloride 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of Src family kinases, inhibits v-Src, c-Fyn, c-Abl, CDK2 and CAMKII with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively.
S6221 Methyl cinnamate Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.