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Fatty Acid Synthase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
E2641 trans-Chalcone Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities.
E2667 IPI-9119 IPI-9119 is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN), which can inhibit the FASN thioesterase domain by promoting acylation of the catalytic serine with an IC50 of 0.3 nM.
S6466 Eicosapentaenoic acid ethyl ester Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
S3576 TVB-3166 TVB-3166 is an orally-available, reversible, potent and selective inhibitor of fatty acid synthase (FASN) with IC50 of 0.042 μM in an in vitro biochemical assay. This compound induces apoptosis, and inhibits in-vivo xenograft tumor growth.
S6248 Fasnall Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity.
S2697 A-769662 A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.
FEBS J, 2025, 10.1111/febs.70247
Arch Biochem Biophys, 2025, 769:110433
J Clin Invest, 2024, 134(22)e181314
Verified customer review of A-769662
S2250 EGCG ((-)-Epigallocatechin Gallate) EGCG ((-)-Epigallocatechin Gallate) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694
Cell Rep, 2025, 44(6):115799
Front Pharmacol, 2024, 15:1403424
Verified customer review of EGCG ((-)-Epigallocatechin Gallate)
S2314 Kaempferol Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
BMC Pharmacol Toxicol, 2025, 26(1):167
Int J Mol Sci, 2023, 24(19)14519
Front Pharmacol, 2023, 14:1047184
Verified customer review of Kaempferol
S1629 Orlistat Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. This compound treatment reduces proliferation, induces apoptosis and arrests cell cycle.
Cell Rep, 2025, 44(7):115901
Acta Pharmacol Sin, 2025, 10.1038/s41401-025-01477-y
J Cell Sci, 2024, 137(20)jcs262162
S8284 Fatostatin HBr Fatostatin HBr is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
Cancer Commun (Lond), 2025, 10.1002/cac2.70038
Cell Commun Signal, 2025, 23(1):438
ACS Omega, 2024, 9(47):47042-47051