Home Metabolism Fatty Acid Synthase

Fatty Acid Synthase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S9392 Praeruptorin B Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.praeruptorin B exerts lipid-lowering effects through inhibits SREBPs and could serve as a possible therapeutic option to improve hyperlipidemia and hyperlipidemia-induced comorbidities.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
Nature Metabolism, 2021, 1466–1477
E2641 trans-Chalcone Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities.
S6466 Eicosapentaenoic acid ethyl ester Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
S3576 TVB-3166 TVB-3166 is an orally-available, reversible, potent and selective inhibitor of fatty acid synthase (FASN) with IC50 of 0.042 μM in an in vitro biochemical assay. This compound induces apoptosis, and inhibits in-vivo xenograft tumor growth.
S6248 Fasnall Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity.
S2697 A-769662 A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.
FEBS J, 2025, 10.1111/febs.70247
Arch Biochem Biophys, 2025, 769:110433
J Clin Invest, 2024, 134(22)e181314
Verified customer review of A-769662
S2250 EGCG ((-)-Epigallocatechin Gallate) EGCG ((-)-Epigallocatechin Gallate) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694
Cell Rep, 2025, 44(6):115799
Front Pharmacol, 2024, 15:1403424
Verified customer review of EGCG ((-)-Epigallocatechin Gallate)
S2314 Kaempferol Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
BMC Pharmacol Toxicol, 2025, 26(1):167
Int J Mol Sci, 2023, 24(19)14519
Front Pharmacol, 2023, 14:1047184
Verified customer review of Kaempferol
S1629 Orlistat Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. This compound treatment reduces proliferation, induces apoptosis and arrests cell cycle.
Cell Rep, 2025, 44(7):115901
Acta Pharmacol Sin, 2025, 10.1038/s41401-025-01477-y
J Cell Sci, 2024, 137(20)jcs262162
S8284 Fatostatin Hydrobromide Fatostatin HBr is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
Cancer Commun (Lond), 2025, 10.1002/cac2.70038
Cell Commun Signal, 2025, 23(1):438
ACS Omega, 2024, 9(47):47042-47051