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DHFR Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S5200 Diaveridine Diaveridine (AI3-23935, CCRIS-3784) is a coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.
S5136 Calcium folinate (Leucovorin calcium) Calcium folinate (Leucovorin calcium) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.Solutions are unstable and should be fresh-prepared.
S1135 Pemetrexed Disodium (LY231514) Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Nat Commun, 2025, 16(1):8932
Cell Death Dis, 2024, 15(8):555
Cell Commun Signal, 2024, 22(1):375
Verified customer review of Pemetrexed Disodium (LY231514)
S5971 Pemetrexed Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. This compound induces autophagy and apoptosis.
Nat Commun, 2025, 16(1):7853
Nat Commun, 2025, 16(1):8476
Sci Adv, 2025, 11(4):eadp4765
S3129 Trimethoprim Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
Cell Rep, 2024, 43(7):114500
Sci Rep, 2024, 14(1):9167
CHALMERS UNIVERSITY OF TECHNOLOGY, 2023,
S5927 Proguanil Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.
Int J Med Sci, 2022, 19(2):233-241
Sci Adv, 2021, 7(27)eabh3032