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Xylitol Autophagy activator

Cat.No.S4546

Xylitol (Adonitol, Ribitol, Xylite, D-Xylitol, Adonite) is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
Xylitol Autophagy activator Chemical Structure

Chemical Structure

Molecular Weight: 152.15

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Quality Control

Purity: >97%
97

Solubility

In vitro
Batch:

DMSO : 30 mg/mL (197.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 30 mg/mL

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 152.15 Formula

C5H12O5

 Storage (From the date of receipt)
CAS No. 87-99-0 Download SDF Storage of Stock Solutions

Synonyms Adonitol, Ribitol, Xylite, D-Xylitol, Adonite Smiles C(C(C(C(CO)O)O)O)O

Mechanism of Action

Targets/IC50/Ki
angiogenesis
In vitro
Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression. This compound strongly inhibits tube formation, migration, and invasion of HUVECs. It decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs.
In vivo
Xylitol triggers the release of insulin in dogs and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03229551 Completed
Chronic Rhinosinusitis|Rhinosinusitis|Sinusitis|Drain Sinus|Endoscopic Sinus Surgery|Biofilms|Bacterial Overgrowth
Ochsner Health System|Tulane University School of Medicine
 March 1 2018 Phase 2|Phase 3

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