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Pramoxine HCl

Cat.No.S4092

Pramoxine(Pramocaine hydrochloride) is a topical local anesthetic that has been shown to have antipruritic properties.
Pramoxine HCl Chemical Structure

Chemical Structure

Molecular Weight: 329.86

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S409201 DMSO]66 mg/mL]false]Water]66 mg/mL]false]Ethanol]66 mg/mL]false Purity: 99.89%
99.89

Chemical Information, Storage & Stability

Molecular Weight 329.86 Formula

C17H27NO3.HCl

 Storage (From the date of receipt)
CAS No. 637-58-1 Download SDF Storage of Stock Solutions

Synonyms Pramocaine hydrochloride Smiles CCCCOC1=CC=C(C=C1)OCCCN2CCOCC2.Cl

Solubility

In vitro
Batch:

DMSO : 66 mg/mL (200.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 66 mg/mL

Ethanol : 66 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro

Pramoxine is used primarily in combination with colloidal oatmeal, hydrocortisone, menthol, and petrolatum. [1]
In vivo

Pramoxine (1.7 mM) causes a lower degree of attenuation of the response to substance P than the responses to acetylcholine, histamine and barium chloride on the guinea-pig ileum. Pramoxine exhibits anesthetic inhibitory potency on the guinea-pig ileum with pKa of 6.4. [2] Pramoxine produces shifts in specific skin temperature at which activation and suppression of both panting and shivering occur in dogs, these changes are interpreted as indicating peripheral mediation in control of thermoregulatory end mechanisms. [3]
References

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