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MCC950 Sodium NLRP3 inhibitor

Cat.No.S7809

MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.

MCC950 Sodium NLRP3 inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 426.46

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Quality Control

Batch: Purity: 99.98%

99.98

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant COX
Other NLRP3 Inhibitors	MCC950 CY-09 INF39 NLRP3 Inflammasome Inhibitor I Dapansutrile BAL-0028 Shionone YQ128 NT-0796 BMS-986299

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Solubility in DMSO or Water

In vitro
Batch:

Water : 43 mg/mL

Ethanol : 43 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

The solubility data above are all experimental results (not literature values).

Water : 85 mg/mL

Ethanol : 85 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

The solubility data above are all experimental results (not literature values).

Water : 85 mg/mL

Ethanol : 85 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

The solubility data above are all experimental results (not literature values).

Water : 85 mg/mL

Ethanol : 85 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

The solubility data above are all experimental results (not literature values).

Water : 85 mg/mL

Ethanol : 43 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

The solubility data above are all experimental results (not literature values).

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Clear solution	saline Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	43.000mg/ml (100.83mM)	Taking the 1 mL working solution as an example, add 43 mg of this product to 1 ml of physiological saline (0.9% NaCL solution), mix evenly to make it clear, The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Read more about MCC950 Sodium solubility in DMSO or water

Search directly for a cell line, or select a cell line to find matched working concentrations

Read more about MCC950 Sodium working concentrations for cell culture treatment

Mechanism of Action

Information	MCC950 Sodium is a potent, highly selective NLRP3 inflammasome inhibitor. It affects NLRP3 signaling by binding to the NACHT domain to block oligomerization, effectively inhibiting inflammasome activation and the subsequent release of pro-inflammatory cytokines IL-1β and IL-18.
Read more about MCC950 Sodium IC50 for cell-based and cell-free assays
Primary Applications and Mechanism of Action

Read more about MCC950 Sodium Mechanism of Action

Chemical Information, Storage & Stability

Molecular Weight	426.46	Formula	C₂₀H₂₃N₂O₅S.Na	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	256373-96-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	CP-456773 Sodium, CRID3 Sodium			Smiles	CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]

Read more about storage & stability

Read more comparative analysis about MCC950 Sodium

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions

Concentration (start):

Dilution-folds:

Computed Result

C1=C0/X	C1:		LOG(C1):
C2=C1/X	C2:		LOG(C2):
C3=C2/X	C3:		LOG(C3):
C4=C3/X	C4:		LOG(C4):
C5=C4/X	C5:		LOG(C5):
C6=C5/X	C6:		LOG(C6):
C7=C6/X	C7:		LOG(C7):
C8=C7/X	C8:		LOG(C8):