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Isosorbide

Name: Isosorbide
Brand: Selleck Chemicals
SKU: S4204
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4204

Isososorbide (D-Isosorbide, Dianhydro-D-glucitol) is a heterocyclic compound that is derived from glucose, used as a diuretic.

Chemical Structure

Molecular Weight: 146.14

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Purity: >97%

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Chemical Information, Storage & Stability

Molecular Weight	146.14	Formula	C₆H₁₀O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	652-67-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	D-Isosorbide,Dianhydro-D-glucitol			Smiles	C1C(C2C(O1)C(CO2)O)O

Solubility

In vitro
Batch:

DMSO : 29 mg/mL (198.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 29 mg/mL

Ethanol : 29 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Isosorbide increases urine volume by increasing the amount of osmotically active solute in the urine. This compound also increases the osmolarity of plasma. It is used to prevent or treat chest pain (angina). It works by relaxing the blood vessels to the heart, so the blood and oxygen supply to the heart is increased. ^[1]
References	[1] http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682348.html

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05954689	Not yet recruiting	Tourniquets\|Anesthesia Conduction\|Anesthetics Local\|Hypertension	Hospital da Luz Portugal	July 10 2023	Not Applicable
NCT05341856	Unknown status	Recurrent Pregnancy Loss	Al-Azhar University	May 1 2022	Early Phase 1
NCT04297241	Completed	Fontan	Children''s Hospital Medical Center Cincinnati	December 12 2019	Phase 2
NCT02053493	Completed	Heart Failure	Adrian Hernandez\|National Heart Lung and Blood Institute (NHLBI)\|Mayo Clinic\|University of Vermont\|Duke University	April 2014	Phase 2
NCT02712125	Completed	Isolated (Idiopathic) Oligohydramnios	Benha University	August 2013	Phase 2\|Phase 3
NCT00930618	Completed	Prolonged Pregnancy\|Nulliparity	Assistance Publique - Hôpitaux de Paris	June 2009	Phase 3

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