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Isosorbide

Cat.No.S4204

Isososorbide (D-Isosorbide, Dianhydro-D-glucitol) is a heterocyclic compound that is derived from glucose, used as a diuretic.
Isosorbide Chemical Structure

Chemical Structure

Molecular Weight: 146.14

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Quality Control

Purity: >97%
97

Solubility

In vitro
Batch:

DMSO : 29 mg/mL (198.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 29 mg/mL

Ethanol : 29 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 146.14 Formula

C6H10O4

 Storage (From the date of receipt)
CAS No. 652-67-5 Download SDF Storage of Stock Solutions

Synonyms D-Isosorbide,Dianhydro-D-glucitol Smiles C1C(C2C(O1)C(CO2)O)O

Mechanism of Action

In vitro

Isosorbide increases urine volume by increasing the amount of osmotically active solute in the urine. This compound also increases the osmolarity of plasma. It is used to prevent or treat chest pain (angina). It works by relaxing the blood vessels to the heart, so the blood and oxygen supply to the heart is increased.

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05954689 Not yet recruiting
Tourniquets|Anesthesia Conduction|Anesthetics Local|Hypertension
Hospital da Luz Portugal
 July 10 2023 Not Applicable
NCT05341856 Unknown status
Recurrent Pregnancy Loss
Al-Azhar University
 May 1 2022 Early Phase 1
NCT04297241 Completed
Fontan
Children''s Hospital Medical Center Cincinnati
 December 12 2019 Phase 2
NCT02053493 Completed
Heart Failure
Adrian Hernandez|National Heart Lung and Blood Institute (NHLBI)|Mayo Clinic|University of Vermont|Duke University
 April 2014 Phase 2
NCT02712125 Completed
Isolated (Idiopathic) Oligohydramnios
Benha University
 August 2013 Phase 2|Phase 3
NCT00930618 Completed
Prolonged Pregnancy|Nulliparity
Assistance Publique - Hôpitaux de Paris
 June 2009 Phase 3

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