Catalog No.S1007 Synonyms: ASP1517
Molecular Weight(MW): 352.34
Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Phase 3.
1 Customer Review
Roxadustat (FG-4592) increases the differentiation of ADMSCs in hypoxic conditions. Representative micrographs showing immunofluorescence of COL I(green) and HIF-1a(green), and DAPI-labelled nuclei(blue) in each group. All cells were detected at day 21 post-induction.
Cell Prolif, 2016, 49(2):173-84.. Roxadustat (FG-4592) purchased from Selleck.
Purity & Quality Control
Choose Selective HIF Inhibitors
|Description||Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Phase 3.|
FG-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. 
|In vitro||DMSO||70 mg/mL (198.67 mM)|
|In vivo||Add solvents individually and in order:
5% DMSO+50% PEG 300+ddH2O
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02964936||Recruiting||Chronic Kidney Disease||Astellas Pharma Inc|FibroGen||January 2017||Phase 3|
|NCT02988973||Recruiting||Chronic Kidney Disease||Astellas Pharma Inc|FibroGen||January 2017||Phase 3|
|NCT02952040||Completed||Healthy Subjects||Astellas Pharma Inc|FibroGen||November 2016||Phase 1|
|NCT02952092||Recruiting||Hemodialysis Chronic Kidney Disease Patients With Anemia||Astellas Pharma Inc|FibroGen||November 2016||Phase 3|
|NCT02805374||Completed||Healthy Subjects||Astellas Pharma Inc|FibroGen||July 2016||Phase 1|
|NCT02780141||Recruiting||ESA-naive Hemodialysis Chronic Kidney Disease Patients With Anemia||Astellas Pharma Inc|FibroGen||June 2016||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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Frequently Asked Questions
Can you tell me what the half-life of the product is, please?
The half-life of S1007 Roxadustat is around 12 hours. Please the reference below: https://www.ncbi.nlm.nih.gov/pubmed/26846333