Roxadustat (FG-4592)

Catalog No.S1007 Synonyms: ASP1517

Roxadustat (FG-4592) Chemical Structure

Molecular Weight(MW): 352.34

Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Phase 3.

Size Price Stock Quantity  
In DMSO USD 64 In stock
USD 70 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

1 Customer Review

  • Roxadustat (FG-4592) increases the differentiation of ADMSCs in hypoxic conditions. Representative micrographs showing immunofluorescence of COL I(green) and HIF-1a(green), and DAPI-labelled nuclei(blue) in each group. All cells were detected at day 21 post-induction.

    Cell Prolif, 2016, 49(2):173-84.. Roxadustat (FG-4592) purchased from Selleck.

Purity & Quality Control

Choose Selective HIF Inhibitors

Biological Activity

Description Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Phase 3.
Targets
HIF α prolyl hydroxylase [1]
(Cell-free assay)
In vitro

FG-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. [1]

Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (198.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
5% DMSO+50% PEG 300+ddH2O
11mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 352.34
Formula

C19H16N2O5

CAS No. 808118-40-3
Storage powder
Synonyms ASP1517

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02964936 Recruiting Chronic Kidney Disease Astellas Pharma Inc|FibroGen January 2017 Phase 3
NCT02988973 Recruiting Chronic Kidney Disease Astellas Pharma Inc|FibroGen January 2017 Phase 3
NCT02952040 Completed Healthy Subjects Astellas Pharma Inc|FibroGen November 2016 Phase 1
NCT02952092 Recruiting Hemodialysis Chronic Kidney Disease Patients With Anemia Astellas Pharma Inc|FibroGen November 2016 Phase 3
NCT02805374 Completed Healthy Subjects Astellas Pharma Inc|FibroGen July 2016 Phase 1
NCT02780141 Recruiting ESA-naive Hemodialysis Chronic Kidney Disease Patients With Anemia Astellas Pharma Inc|FibroGen June 2016 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Can you tell me what the half-life of the product is, please?

  • Answer:

    The half-life of S1007 Roxadustat is around 12 hours. Please the reference below: https://www.ncbi.nlm.nih.gov/pubmed/26846333

Related Antibodies

HIF Signaling Pathway Map

Related HIF Products

Tags: buy Roxadustat (FG-4592) | Roxadustat (FG-4592) supplier | purchase Roxadustat (FG-4592) | Roxadustat (FG-4592) cost | Roxadustat (FG-4592) manufacturer | order Roxadustat (FG-4592) | Roxadustat (FG-4592) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID