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Famprofazone

Cat.No.S4327

Famprofazone (Geodowin, FA, Famprofazonum) is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolone series. This compound is an analgesic used for fever and pain relief.
Famprofazone Chemical Structure

Chemical Structure

Molecular Weight: 377.52

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Quality Control

Batch: S432701 Ethanol]12 mg/mL]false]DMSO]Insoluble]false]Water]Insoluble]false Purity: 98%
98

Solubility

In vitro
Batch:

Ethanol : 12 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 377.52 Formula

C24H31N3O

 Storage (From the date of receipt)
CAS No. 22881-35-2 Download SDF Storage of Stock Solutions

Synonyms Geodowin, FA, Famprofazonum Smiles CC(C)C1=C(N(N(C1=O)C2=CC=CC=C2)C)CN(C)C(C)CC3=CC=CC=C3

Mechanism of Action

In vitro

Famprofazone has been known to produce methamphetamine as an active metabolite, with 15-20% of an oral dose being converted to it. This compound has occasionally been implicated in causing false positives on drug tests for amphetamines.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05940766 Not yet recruiting
Pediatric Oncology Patients With Risk for Infections
Insel Gruppe AG University Hospital Bern|ETH Zurich
 October 1 2024 Not Applicable
NCT05689359 Withdrawn
Breast Cancer|Gynecologic Cancer|Early-stage Breast Cancer|Peripheral Neuropathy|Chemotherapy-induced Peripheral Neuropathy
University of Arizona
 June 2024 Phase 2
NCT06078384 Not yet recruiting
Triple-negative Breast Cancer
UNICANCER|MSD France|Vall d''Hebron Institute of Oncology|SOLTI Breast Cancer Research Group
 June 30 2024 Phase 2
NCT06308718 Not yet recruiting
Krabbe Disease
Forge Biologics Inc
 June 2024 --

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