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Etofibrate

Cat.No.S4264

Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.
Etofibrate Chemical Structure

Chemical Structure

Molecular Weight: 363.79

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Quality Control

Batch: S426401 DMSO]73 mg/mL]false]Ethanol]73 mg/mL]false]Water]Insoluble]false Purity: 99.85%
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99.85

Solubility

In vitro
Batch:

DMSO : 73 mg/mL (200.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 73 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 363.79 Formula

C18H18ClNO5

 Storage (From the date of receipt)
CAS No. 31637-97-5 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC(C)(C(=O)OCCOC(=O)C1=CN=CC=C1)OC2=CC=C(C=C2)Cl

Mechanism of Action

In vitro
Etofibrate treatment heightens the cytosolic glycerol-3-phosphate dehydrogenase activity and the total carnitine concentration in the liver of rats, whereas it reduces triacylglycerol and cholesterol concentrations. This compound decreases plasma levels of cholesterol, triacylglycerols, free fatty acids (FFA) and glycerol, as well as the total and unesterified cholesterol concentrations, in liver microsomes of rats. It increases the activity of liver cytosolic glycerol-3-P dehydrogenase in the rats, whereas it decreases the activity of both microsomal HMG-CoA reductase and cholesterol 7 alpha-hydroxylase and does not affect acyl-CoA: cholesterol acyltransferase (ACAT). The compound decreases the availability of lipolytic products in the liver by acting on their release from adipose tissue and on their intrinsic hepatic metabolism. It stimulates the rate of fatty acid re-esterification when incubations are done under basal conditions in epididymal fat pad pieces from fed rats.
In vivo
Etofibrate (1.2 mM/g) decreases plasma FFA levels in male Sprague-Dawley rats, this compound enhances or decreases plasma glycerol levels depending on both the dose and the time after treatment. This chemical (200 mg/kg) causes a significant inhibition of the proliferation of the smooth muscle cells in the intimal proliferate which consequently results in a less pronounced plaque in a rabbit model of atherosclerosis.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/2371790/

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