Home Others Others Dropropizine

research use only

Dropropizine

Cat.No.S4138

Dropropizine (UCB-1967,(±)- Dropropizine) is a racemic non-opiate antitussive agent, it is used as a cough suppressant.
Dropropizine Chemical Structure

Chemical Structure

Molecular Weight: 236.31

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S413801 DMSO]47 mg/mL]false]Ethanol]47 mg/mL]false]Water]11 mg/mL]false Purity: 99.41%
99.41

Chemical Information, Storage & Stability

Molecular Weight 236.31 Formula

C13H20N2O2

 Storage (From the date of receipt)
CAS No. 17692-31-8 Download SDF Storage of Stock Solutions

Synonyms UCB-1967,(±)- Dropropizine Smiles C1CN(CCN1CC(CO)O)C2=CC=CC=C2

Solubility

In vitro
Batch:

DMSO : 47 mg/mL (198.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 47 mg/mL

Water : 11 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro

Dropropizine shows neither mutagenic nor clastogenic effects in Chinese hamster V79 and human EUE cells, while Lithium carbonicum manifestes a weak and mazindol a medium genotoxic response which is in both cases reduce in the presence of microsomal fraction S9. [1]
In vivo

Dropropizine exhibits antitussive activity in cats noticeably lower than Pinacidil and Codeine. [2] This compound (100 mg/kg, b.w., intraperitoneally) has similar antitussive activity as that of EEPF (200 mg/kg, b.w., orally). [3] It exhibits antitussive activity of 28.3% in mechanically induced cough in nonanaesthetized cats, comparable to prenoxdiazine (24.7%).[4] This chemical (dropro–dose 100 mg/kg b.w.) exhibits comparable cough-suppressing effect of mucilage from S. althaeae. It (dropro–dose 100 mg/kg b.w.) exhibits antitussive activity less than E. officinalis on the mechanically induced cough reflex under experimental conditions. [5]
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/10683875/
  • [5] http://www.sciencedirect.com/science/article/pii/S1572557X05020076

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.