Dexamethasone Acetate

Synonyms: NSC 39471,Dexamethasone 21-acetate

Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

Dexamethasone Acetate Chemical Structure

Dexamethasone Acetate Chemical Structure

CAS No. 1177-87-3

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Biological Activity

Description Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Targets
interleukin receptor [1]
In vitro
In vitro

Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. [1] Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. [2]Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. [3] Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression. [5]

Experimental Result Images Methods Biomarkers Images PMID
Western blot p-AKT / AKT GRP78 / GRP94 / pIREα / IREα / peIF2α / eIF2α CHOP BCRP / P-gp / Mrp2 29436611
Immunofluorescence GRP78 24691439
Growth inhibition assay Cell viability 22719835
In Vivo
In vivo

Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. [4] Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats. [5]

Animal Research Animal Models Sprague-Dawley rats
Dosages 100 μg/kg
Administration Intraperitoneal injection
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06351644 Not yet recruiting
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Adriana Rossi|Icahn School of Medicine at Mount Sinai
June 3 2024 Phase 1|Phase 2
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Spinal Stenosis Lumbar|Disc Degeneration|Disc Disease|Fusion of Spine|Surgery
Potsawat Surabotsopon|Thammasat University Hospital
May 1 2024 Phase 4
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Acute Lymphoblastic Leukemia
University of Aarhus
April 11 2024 --

Chemical Information & Solubility

Molecular Weight 434.5 Formula

C24H31FO6

CAS No. 1177-87-3 SDF Download Dexamethasone Acetate SDF
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 87 mg/mL ( (200.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


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