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D3-βArr TSH Receptor modulator

Name: D3-βArr
Brand: Selleck Chemicals
SKU: S0319
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S0319

D3-βArr(NCGC00379308) is a positive allosteric modulator of thyrotropin receptor (TSHR) that modulates TSH-induced β-Arr 1 translocation.

Chemical Structure

Molecular Weight: 333.43

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Quality Control

Batch: S031901 DMSO]67 mg/mL]false]Ethanol]33 mg/mL]false]Water]Insoluble]false Purity: 99.96%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.96

Related Targets	Adrenergic Receptor Estrogen/progestogen Receptor GPR Androgen Receptor Glucocorticoid Receptor ACE RAAS Progesterone Receptor Opioid Receptor PGES
Other TSH Receptor Inhibitors	Carbimazole TSHR antagonist S37

Solubility

In vitro
Batch:

DMSO : 67 mg/mL (200.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 33 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	333.43	Formula	C₂₀H₂₃N₅	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	662164-09-2	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	NCGC00379308			Smiles	CC(C1=CC=CC=C1)NC2=NC(=NC3=CC=CC=C32)N4CCNCC4

Mechanism of Action

Targets/IC₅₀/Ki	TSHR
References	[1] https://pubmed.ncbi.nlm.nih.gov/29089368/

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