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Chromocarb

Name: Chromocarb
Brand: Selleck Chemicals
SKU: S4208
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4208

Chromocarb (Atremon) is a vasoprotectant. This compound is a vasoprotectant. This chemical is a vasoprotectant.

Chemical Structure

Molecular Weight: 190.15

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Quality Control

Batch: S420801 DMSO]38 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.53%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

99.53

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Solubility

In vitro
Batch:

DMSO : 38 mg/mL (199.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	190.15	Formula	C₁₀H₆O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	4940-39-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Atremon			Smiles	C1=CC=C2C(=C1)C(=O)C=C(O2)C(=O)O

Mechanism of Action

In vivo

Chromocarb is a vascular protective agent used in the treatment of venous disorders and microvascular affections. Peroral treatment of rats with this compound significantly reduces the degradation of the vascular wall by intravenous collagenase. This chemical treatment induces a lesser permeability increase of the BBB, a shorter recovery time, lower hydroxyproline levels in the cerebrospinal fluid and a lesser decrease of the collagen content of the brain capillary basal lamina. This compound (50 mg/kg) is more effective than vitamin C in the prevention of glutathione oxidation in blood. It is the most effective compound in the prevention of exercise-induced lipid peroxidation (malondialdehyde) in plasma.

References

[1] https://pubmed.ncbi.nlm.nih.gov/3034470/
[2] https://pubmed.ncbi.nlm.nih.gov/11881979/

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