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Canrenone Mineralocorticoid Receptor antagonist

Name: Canrenone
Brand: Selleck Chemicals
SKU: S5273
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S5273

Canrenone (Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone), a cardiovascular drug, a sort of steroid, is spironolactone's major metabolite and has been widely used as a nonselective aldosterone receptor antagonist clinically to treat heart failure, high blood pressure, edema, liver ascites, and other cardiovascular diseases.

Chemical Structure

Molecular Weight: 340.46

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Quality Control

Batch: S527301 DMSO]68 mg/mL]false]]]false]]]false Purity: 99.89%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.89

Related Targets	Adrenergic Receptor Estrogen/progestogen Receptor GPR Androgen Receptor Glucocorticoid Receptor ACE RAAS Progesterone Receptor Opioid Receptor PGES
Other Mineralocorticoid Receptor Inhibitors	Apararenone Esaxerenone (CS-3150)

Solubility

In vitro
Batch:

DMSO : 68 mg/mL (199.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	340.46	Formula	C₂₂H₂₈O₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	976-71-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone			Smiles	CC12CCC(=O)C=C1C=CC3C2CCC4(C3CCC45CCC(=O)O5)C

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06021860	Not yet recruiting	Edema Due to Heart Failure or Cirrhosis	CMP Development LLC	June 2024	Phase 4
NCT01083290	Completed	Healthy	Orion Corporation Orion Pharma	April 2010	Phase 1

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Handling Instructions

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