Name: Bisacodyl
Brand: Selleck Chemicals
SKU: S4047
Availability: InStock
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Batch: S404701 DMSO]72 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.9%

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COA
NMR
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Datasheet

99.9

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Solubility

In vitro
Batch:

DMSO : 72 mg/mL (199.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

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%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	361.39	Formula	C₂₂H₁₉NO₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	603-50-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(=O)C)C3=CC=CC=N3

Mechanism of Action

In vitro	Bisacodyl (10 μg/mL) increases mRNA expression level of TNF-α, COX2 and PGE2 in Raw264.7 cells.
In vivo	Bisacodyl (20 mg/kg) results in a decrease in AQP3 protein expression and increased mRNA expression level of TNF-α in the colon of rats. This compound inhibits water absorption in rat jejunum, ileum, and colon, the degree of inhibition is linearly related to the logarithm of the bisacodyl concentration over the range of 0.05 mg to 2.0 mg per 100 mL. This chemical (10 mg/kg, intragastrically) induces a significant decrease in jejunal NOS activity in rats. It (10 mg/kg, intragastrically) increases the distance traveled by the marker in all time periods. It (5.9 mg/kg) decreases significantly jejunal and colonic (Na + K) ATPase activity as compared to saline-treated rats. This compound (5.9 mg/kg) increases significantly jejunal and colonic PGE2 content and stimulates jejunal and colonic adenyl cyclase activity as compared to those in control rats without affecting cAMP content. It (4.3 mg/kg) coupled with AOM increases the number of crypt per focus, but not the number of tumors in rats. This chemical (43 mg/kg) significantly increases the number of crypt per focus and tumors in rats.
References	[1] https://pubmed.ncbi.nlm.nih.gov/21868635/ [2] https://pubmed.ncbi.nlm.nih.gov/849815/ [3] https://pubmed.ncbi.nlm.nih.gov/9282971/ [4] https://pubmed.ncbi.nlm.nih.gov/6249558/ [5] https://pubmed.ncbi.nlm.nih.gov/11693267/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06219707	Not yet recruiting	Irritable Bowel Syndrome With Constipation	Nanyang Technological University\|National University of Singapore	March 1 2024	Not Applicable
NCT05770960	Completed	Opioid-Induced Constipation	Universitaire Ziekenhuizen KU Leuven	June 27 2018	Phase 4
NCT03279341	Completed	Chronic Constipation	University Hospital Gasthuisberg	December 3 2012	Phase 4
NCT01424228	Completed	Constipation	Shire\|Takeda	April 6 2011	Phase 4

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Bisacodyl

Chemical Structure

Molecular Weight: 361.39