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Tie2 kinase inhibitor Chemical Structure
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Biological Activity
Tie2 kinase inhibitor is a potent, reversible, and ATP-binding site-targeting Tie2 inhibitor with an IC50 of 250 nM. It is a cell-permeable pyridinylimidazole compound. It has ~ 200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over VEGFR2, VEGFR3, and PDGFR1β. It was shown to exhibit antiangiogenesis activity in a Matrigel assay (70% reduction, 50 mg/kg/0.5 day, i.p.) and inhibit the growth of xenografted tumor (no apparent growth up to 20 days, 25 mg/kg/0.5 day, i.p.) in mice in vivo.[1]
Chemical Information
| Molecular Weight (WM): | 439.53 |
|---|---|
| Formula: | C26H21N3O2S |
| CAS No.: | 948557-43-5 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥35mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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