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6-Methylcoumarin

Cat.No.S4802

6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.
6-Methylcoumarin Chemical Structure

Chemical Structure

Molecular Weight: 160.17

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Quality Control

Batch: S480201 DMSO]32 mg/mL]false]]]false]]]false Purity: 99.99%
99.99

Solubility

In vitro
Batch:

DMSO : 32 mg/mL (199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 160.17 Formula

C10H8O2

 Storage (From the date of receipt)
CAS No. 92-48-8 -- Storage of Stock Solutions

Synonyms Toncarine Smiles CC1=CC2=C(C=C1)OC(=O)C=C2

Mechanism of Action

In vitro
Transport experiments with Caco-2 cells show that 6-Methylcoumarin presents high permeability at all concentrations evaluated. This finding suggests that this compound could be transported across the gut wall by passive diffusion.
In vivo
The plasma concentration-time curve shows that the maximum concentration (Cmax) is 17.13 ± 2.90 µg/mL at maximum time (Tmax) of 30 min for the oral route (200 mg/kg) and Cmax 26.18 ± 2.47 µg/mL at 6.0 min for the intraperitoneal administration (200 mg/kg), with elimination constant of (Ke) 0.0070/min and a short life half time of (T1/2) lower that 120 min. This compound has high accumulation in the liver, and widespread distribution in all the organs evaluated. The oral bioavailability (F) of this chemical is 45% in Wistar rats.
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