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4-Aminobenzoic acid

Cat.No.S4510

4-Aminobenzoic acid (para-Aminobenzoic acid) is an intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi.
4-Aminobenzoic acid Chemical Structure

Chemical Structure

Molecular Weight: 137.14

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Quality Control

Batch: S451001 DMSO]27 mg/mL]false]Ethanol]27 mg/mL]false]Water]Insoluble]false Purity: 99.97%
99.97

Solubility

In vitro
Batch:

DMSO : 27 mg/mL (196.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 27 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 137.14 Formula

C7H7NO2

 Storage (From the date of receipt)
CAS No. 150-13-0 Download SDF Storage of Stock Solutions

Synonyms para-Aminobenzoic acid Smiles C1=CC(=CC=C1C(=O)O)N

Mechanism of Action

In vivo
Plants produce PABA in their chloroplasts, and store it as a glucose ester (pABA-Glc) in their tissues. Humans lack the enzymes to convert PABA to folate, so require folate from dietary sources such as green leafy vegetables. In humans, PABA is considered nonessential and, although it has been referred to historically as "vitamin Bx", is no longer recognized as a vitamin, because most people have colon bacteria that generate PABA.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02481505 Completed
Short Duration Lower Limb Surgery Via Spinal Anaesthesia
Sintetica SA|Cross S.A.
 June 2015 Phase 2
NCT01773304 Completed
Obesity|Bone Metabolism
University of Copenhagen|Danish Agriculture and Food Council
 December 2012 Not Applicable

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