UNC2881

Catalog No.S7325

For research use only.

UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.

UNC2881 Chemical Structure

CAS No. 1493764-08-1

Selleck's UNC2881 has been cited by 2 Publications

Purity & Quality Control

Choose Selective Mertk Inhibitors

Biological Activity

Description UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.
Targets
Mer [1]
(Cell-free assay)
Tyro3 [1]
(Cell-free assay)
Axl [1]
(Cell-free assay)
4.3 nM 250 nM 360 nM
In vitro

UNC2881 inhibits Mer kinase activity in 697 B-ALL cells with IC50 of 22 nM, and inhibits collagen-stimulated platelet aggregation. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
697 B-ALL cells NVnBfIJpTnWwY4Tpc44h[XO|YYm= Mk\DNUBp NH24dmlKdmirYnn0bY9vKG:oIF3ldkBscW6jc3WgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIE[5O{BDNUGOTDDj[YxteyCjZoTldkAyKGi{IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqeyxiSVO1NF0xNjB{MjFOwG0> MUWyOFIyQTd5OB?=
mouse 32D-EMC cells NGOxdphHfW6ldHnvckBie3OjeR?= M1HreWlvcGmkaYTpc44hd2ZiRVfGMYlv\HWlZXSgbJVu[W5iaX70doFk\WyudXzhdkBld22jaX6gc4YhVWW{L3X4eJJi[2WubIXsZZIh\G:vYXnuJI9nKEWJRmKgdIhwe3Cqb4L5cIF1cW:wIHX4dJJme3OnZDDpckBud3W|ZTCzNmQuTU2FIHPlcIx{KGGodHXyJFEhcHJiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ M3WzfFI1OjF7N{e4
In vivo UNC2881 have high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability in mice. [1]

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Swiss albino mice
  • Dosages: ~3 mg/kg
  • Administration: i.v. or p.o.

Solubility (25°C)

In vitro

DMSO 92 mg/mL
(198.45 mM)
Ethanol 5 mg/mL warmed
(10.78 mM)
Water Insoluble

Chemical Information

Molecular Weight 463.58
Formula

C25H33N7O2

CAS No. 1493764-08-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCNC1=NC=C(C(=N1)NC2CCC(CC2)O)C(=O)NCC3=CC=C(C=C3)N4C=CN=C4

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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