UNC2881

For research use only.

Catalog No.S7325

2 publications

UNC2881 Chemical Structure

CAS No. 1493764-08-1

UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.

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Biological Activity

Description UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.
Targets
Mer [1]
(Cell-free assay)
Tyro3 [1]
(Cell-free assay)
Axl [1]
(Cell-free assay)
4.3 nM 250 nM 360 nM
In vitro

UNC2881 inhibits Mer kinase activity in 697 B-ALL cells with IC50 of 22 nM, and inhibits collagen-stimulated platelet aggregation. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
697 B-ALL cells MYjGeY5kfGmxbjDhd5NigQ>? M4rhfVEhcA>? MXvJcohq[mm2aX;uJI9nKE2ncjDrbY5ie2VicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKDZ7NzDCMWFNVCClZXzsd{Bi\nSncjCxJIhzKGK7IGfld5Rmem5iYnzveEBidmGueYPpd{whUUN3ME2wMlAzOiEQvF2= NYDaXFF1OjR{MUm3O|g>
mouse 32D-EMC cells MoLxSpVv[3Srb36gZZN{[Xl? M4DEWmlvcGmkaYTpc44hd2ZiRVfGMYlv\HWlZXSgbJVu[W5iaX70doFk\WyudXzhdkBld22jaX6gc4YhVWW{L3X4eJJi[2WubIXsZZIh\G:vYXnuJI9nKEWJRmKgdIhwe3Cqb4L5cIF1cW:wIHX4dJJme3OnZDDpckBud3W|ZTCzNmQuTU2FIHPlcIx{KGGodHXyJFEhcHJiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ MoDBNlQzOTl5N{i=

... Click to View More Cell Line Experimental Data

In vivo UNC2881 have high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability in mice. [1]

Protocol

Animal Research:

[1]

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  • Animal Models: Swiss albino mice
  • Dosages: ~3 mg/kg
  • Administration: i.v. or p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 92 mg/mL (198.45 mM)
Ethanol 5 mg/mL warmed (10.78 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 463.58
Formula

C25H33N7O2

CAS No. 1493764-08-1
Storage powder
in solvent
Synonyms N/A
Smiles CCCCNC1=NC=C(C(=N1)NC2CCC(CC2)O)C(=O)NCC3=CC=C(C=C3)N4C=CN=C4

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID