- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S1343||Ginkgolide B||<1 mg/mL||85 mg/mL||<1 mg/mL|
- PAFR Inhibitors (1)
|Catalog No.||Information||Product Use Citations||Product Validations|
Ginkgolide B is a PAFR antagonist with IC50 of 3.6 μM.
Functional recovery of forelimb strength (a, c) and rotarod performance (b, d) in 8-week-old wild-type (a, b) and wild-type with SCI (c, d) mice treated with DMSO vehicle solution or GB. Asterisk represents p<0.05, SCI w/GB(10-42dpi) vs. SCI w/DMSO. Number sign represents p<0.05, SCI w/GB(1-10dpi) vs. SCI w/DMSO. Plus sign represents p<0.05, GB(10-42dpi) vs. SCI w/GB (1–10 dpi). The wild-type mice injected with GB for 42 days (n=4) demonstrated similar forelimb strength and rotarod performance as those wild-type mice injected with DMSO vehicle solution (n=4). Compared to the wild-type SCI mice injected with DMSO vehicle solution for 42 days after injury (n=10), administration of GB during the subacute and chronic phases (n=7) showed an enhanced functional recovery than that during the acute inflammatory phase (n=12) after SCI.