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NF-κB Activators

Cat.No. Product Name Information Product Use Citations Product Validations
E1351 NF-κΒ activator 1 NF-κΒ activator 1(Compound 32) is a potent NF-κΒ activator, with an EC50 of 0.9 μM.
Cancer Cell Int, 2025, 25(1):408
Chin Med, 2025, 20(1):170
E7641 TNF-α (31-45), human TNF-α (31-45), human is a potent activator of NF-kB pathway. It is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis. It can be used in research of autoimmune diseases.
S2979 CU-T12-9 CU-T12-9 is a specific agonist of Toll-like receptor (TLR) 1/2 with EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay. This compound activates both the innate and the adaptive immune systems. It signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.
Nat Commun, 2025, 16(1):2743
Biomedicine & Pharmacotherapy, 2023, 114638
Biomed Pharmacother, 2023, 162:114638
E8271New Sanguinarine citrate Sanguinarine (gluconate) is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis. It activates reactive oxygen species (ROS), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB (NF-κB) signaling pathways to induce apoptosis in head and neck tumor cells and animal models. It also exhibits potent anti-bacterial and anti-inflammatory activities.