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Mitophagy Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
E2988 Sulfosuccinimidyl Oleate Sodium (SSO) Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain with IC50 of 4 μM. It inhibits CD36 mediated LCFA transport. It exhibits anti-inflammatory effect.
Int J Biol Sci, 2025, 21(5):2118-2134
Sci Rep, 2025, 15(1):30552
Front Cell Dev Biol, 2021, 9:687169
S1102 U0126-EtOH U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.
Nat Commun, 2025, 16(1):2192
Nat Commun, 2025, 16(1):7156
Adv Sci (Weinh), 2025, 12(44):e11726
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S7162 Mdivi-1 Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhances apoptosis.
J Hazard Mater, 2025, 495:138854
Redox Biol, 2025, 86:103818
J Nanobiotechnology, 2025, 23(1):437
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S7046 Brefeldin A (BFA chemical) Brefeldin A (BFA) is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.
Protein Cell, 2025, pwaf020
Cancer Commun (Lond), 2025, 10.1002/cac2.70036
J Integr Plant Biol, 2025, 67(8):2229-2244
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S1759 Pitavastatin (NK-104) Calcium Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.
bioRxiv, 2025, 2025.08.10.669191
Nat Commun, 2024, 15(1):4099
J Immunother Cancer, 2024, 12(11)e009805
Verified customer review of Pitavastatin (NK-104) Calcium
S9424 Liensinine diperchlorate Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.