Home Apoptosis MDM2/MDMX

MDM2/MDMX Antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S1061 Nutlin-3 Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.
Cancer Discov, 2025, 15(1):69-82
iScience, 2025, 28(6):112635
Biomed Rep, 2025, 22(4):65
Verified customer review of Nutlin-3
S7649 SAR405838 SAR405838 is an orally available MDM2 antagonist with Ki of 0.88 nM. This compound is a diastereomer of MI-773 (CAS: 1303607-07-9). Phase 1.
Nat Genet, 2025, 57(1):140-153
Pharmaceutics, 2023, 15(4)1274
bioRxiv, 2023, 10.1101/2023.03.10.531074
Verified customer review of SAR405838
S8065 Nutlin-3b Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of this compound as in comparison with opposite (-)-enantiomer Nutlin-3a.
Life Sci Alliance, 2022, 5(4)e202101157
Electrophoresis, 2015, 36(24):3101-4
Verified customer review of Nutlin-3b
S7489 YH239-EE YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
Cell Stem Cell, 2018, 23(4):544-556