MAP4K Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
E1161	CompK	CompK (compound K), a potent and selective hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) small molecule inhibitor, significantly improves human T-cell functions, with enhanced T-cell receptor avidity to recognize tumor-associated antigens and tumor cytolytic activity by CD8+ T cells.
E4722	GNE-495	GNE-495 is a potent and selective inhibitor of MAP4K4 with an IC50 value of 3.7 nM. It demonstrates excellent potency and good Pharmacokinetics in in vivo efficacy in a retinal angiogenesis model.
E0946	MAP4K4-IN-3	MAP4K4-IN-3 is a potent and selective Mitogen-activated protein kinase 4 (MAP4K4) inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay.
S8868	NG25	NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.	Int J Biol Sci, 2024, 20(2):606-620 Biochem J, 2022, 479(20):2195-2216 Lab Invest, 2021, 10.1038/s41374-021-00671-w