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Cat.No. Product Name Information Product Use Citations Product Validations
E7975 CCG-63802 CCG-63802 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gαo interaction, with an IC50 value of 1.9 μM.
E7993 CCG-63808 CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.
E4716 QS11 QS11 acts as an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 regulates Wnt/β-catenin signaling by interacting with ARF GTPase-activating protein 1 (ARFGAP1) and influences protein trafficking. Additionally, QS11 suppresses the migration of breast cancer cells that overexpress ARFGAP1.
S7606 RBC8 RBC8 is a selective inhibitor of the GTPases RalA and RalB by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases Ras and RhoA.
Cell Res, 2025, 10.1038/s41422-025-01085-9
J Exp Clin Cancer Res, 2022, 41(1):301
Haematologica, 2019, 10.3324/haematol.2019.223024
Verified customer review of RBC8
S7607 BQU57 BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.
J Adv Res, 2024, S2090-1232(24)00171-1
PLoS One, 2019, 14(4):e0214764
S2901 CCG 50014 CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.
Mol Pharmacol, 2018, 93(1):25-35
E1047 NAV-2729 NAV-2729, an inhibitor of Arf6 activation which directly binds to Arf6, also inhibits all Arf guanine nucleotide exchange factors (ArfGEFs) with a strongest effect against BRAG2 and Arf1 .