E3 Ligase Antagonists

Featured Inhibitors
Inhibitors (28)
Modulators (5)
Chemicals (7)
Activator (1)
Antagonists (2)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S1061	Nutlin-3	Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.	Cancer Discov, 2025, 15(1):69-82 iScience, 2025, 28(6):112635 Biomed Rep, 2025, 22(4):65
S1172	Serdemetan (JNJ-26854165)	Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.	Elife, 2025, 14e75393 J Physiol, 2025, 603(19):5477-5508 Signal Transduct Target Ther, 2022, 7(1):97

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S1061

Nutlin-3

Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.

Cancer Discov, 2025, 15(1):69-82

iScience, 2025, 28(6):112635

Biomed Rep, 2025, 22(4):65

S1172

Serdemetan (JNJ-26854165)

Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.

Elife, 2025, 14e75393

J Physiol, 2025, 603(19):5477-5508

Signal Transduct Target Ther, 2022, 7(1):97

Verified customer review of Serdemetan (JNJ-26854165)