ADC Linker Inhibitors

Cat.No.	Product Name	Information
S0651	N-Butanoyl-L-homoserine lactone	N-Butyryl-L-homoserine lactone (N-Butanoyl-L-homoserine lactone, N-Butyrylhomoserine lactone, C4-HSL) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N-Butyryl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism.
S0654	Mal-PEG4-NHS ester	Mal-PEG4-NHS ester is a non-cleavable ADC linker containing a Maleimide group, 4-unit PEG and an NHS ester.
S0655	Propargyl-PEG4-NHS ester	Propargyl-PEG4-NHS ester is a 4-unit amine reactive PEG linker for antibody-drug-conjugation (ADC) which is noncleavable.
S9795	Deruxtecan	Deruxtecan is an ADC drug-linker conjugate composed of the cleavable glycine–glycine–phenylalanine–glycine tetrapeptide-based linker, a self-immolative amino methylene spacer, and a novel topoisomerase 1 inhibitor payload that is a derivative of exatecan (DX-8951).
S2982	DM1-SMCC	DM1-SMCC (SMCC-DM1) is an antibody drug conjugate (ADC)-linker consists of a potent microtubule-disrupting agent DM1 and a linker SMCC.
S3141	Maleimide	Maleimide exhibits fluorescence quenching ability and can be used for the specific detection of thiol analytes as fluorogenic probes. This compound is also used for production of antibody-drug conjugate (ADC) which is used in cancer research.
S0572	SMCC	SMCC (Succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate) is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. This compound-conjugated antigen couples spleen cells to induce antigen-specific immune responses.
S6661	VcMMAE (MC-Vc-PAB-MMAE)	VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.
S0603	m-PEG12-amine	m-PEG12-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. This compound is also a non-cleavable 12-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0675	Azide-PEG5-Tos	Azide-PEG5-Tos (Azido-PEG5-OTs) is a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).