ADC Linker Chemicals

Cat.No.	Product Name	Information	Product Use Citations
S0657	DSS Crosslinker	DSS Crosslinker (Disuccinimidyl suberate) is a membrane permeable homobifunctional crosslinking agent and a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).	J Pharm Anal, 2025, 15(1):101069 Cell Death Dis, 2022, 13(6):524
S6832	MC-VC-PAB-PNP	MC-Val-Cit-PAB-PNP (Mc-Val-Cit-PABC-PNP) is a cathepsin cleavable ADC peptide linker that is applicable to the synthesis of antibody-drug conjugates (ADCs).
S0091	Fmoc-Val-Ala-PAB	Fmoc-Val-Ala-PAB (Fmoc-Val-Ala-PAB-OH) is a useful and cleavalbe linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery.
S0335	Boc-Val-Cit-PAB-PNP	Boc-Val-Cit-PAB-PNP is a cleavable linker of ADC that is used in the synthesis of antibody-drug conjugates (ADCs).
S0566	Sulfo-SMCC sodium	Sulfo-SMCC sodium is a hetero-bifunctional, noncleavable ADC crosslinker which consists of N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups.
S0586	Succinic anhydride	Succinic anhydride (SA, Succinyl Oxide, Butanedioic Anhydride) is a cyclic anhydride that can be used in the homogeneous chemical modification of cellulose and as a noncleavable ADC linker that reacts with other compound to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.
S0626	DSP Crosslinker	DSP Crosslinker is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0651	N-Butanoyl-L-homoserine lactone	N-Butyryl-L-homoserine lactone (N-Butanoyl-L-homoserine lactone, N-Butyrylhomoserine lactone, C4-HSL) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N-Butyryl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism.
S0654	Mal-PEG4-NHS ester	Mal-PEG4-NHS ester is a non-cleavable ADC linker containing a Maleimide group, 4-unit PEG and an NHS ester.
S0655	Propargyl-PEG4-NHS ester	Propargyl-PEG4-NHS ester is a 4-unit amine reactive PEG linker for antibody-drug-conjugation (ADC) which is noncleavable.
S9795	Deruxtecan	Deruxtecan is an ADC drug-linker conjugate composed of the cleavable glycine–glycine–phenylalanine–glycine tetrapeptide-based linker, a self-immolative amino methylene spacer, and a novel topoisomerase 1 inhibitor payload that is a derivative of exatecan (DX-8951).
S2982	DM1-SMCC	DM1-SMCC (SMCC-DM1) is an antibody drug conjugate (ADC)-linker consists of a potent microtubule-disrupting agent DM1 and a linker SMCC.
S3141	Maleimide	Maleimide exhibits fluorescence quenching ability and can be used for the specific detection of thiol analytes as fluorogenic probes. This compound is also used for production of antibody-drug conjugate (ADC) which is used in cancer research.
S0572	SMCC	SMCC (Succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate) is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. This compound-conjugated antigen couples spleen cells to induce antigen-specific immune responses.
S0603	m-PEG12-amine	m-PEG12-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. This compound is also a non-cleavable 12-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0675	Azide-PEG5-Tos	Azide-PEG5-Tos (Azido-PEG5-OTs) is a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).