Telomerase Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S1186	BIBR 1532	BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. This compound induces apoptosis in cancer cells.	JCO Precision Oncology, September 16, 2019, 1-20 Nature Communications, July 3, 2020, 3321 Frontiers in Veterinary Science, January 20, 2021, 620776
S1319	Costunolide	Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.	Journal of Traditional and Complementary Medicine, 2023, 345-357 J Tradit Complement Med, 2023, 13(4):345-357 Pathol Res Pract, 2022, 236:153966
S8118	RHPS 4 methosulfate	RHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar.	The Journal of Physical Chemistry B, July 6, 2023, 5859-5868 Clinical Science, January 31, 2020, 193-205 Journal of the American Chemical Society, December 15, 2021, 20779-20791
E1302	Braco-19 trihydrochloride	Braco-19 trihydrochloride(BRAC-O19, BRACO19 3HCl) is a G-quadruplex-stabilizing agent and an inhibitor of telomere/telomerase. It establishes antiviral activity against HIV-1 and anticancer effects by inhibiting telomerase capping and catalytic functions.
E4620	L-778123 hydrochloride	L-778123 hydrochloride is a potent dual inhibitor of farnesyl protein transferase (FPTase) with an IC50 of 2 nM and geranylgeranyl protein transferase I (GGPTase-I) with an IC50 of 98 nM. It also displays promising anti-leukemia activity.
E1739	MST-312	MST-312(Telomerase Inhibitor IX) is an inhibitor of telomerase. This compound is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). It exhibits high chemical stability, lowers the effective dose in the induction of telomere shortening, and lowers drug resistance. This chemical can be used for the research of cancer. It can also be used as a promising strategy in the treatment of multiple myeloma (MM).
S2250	EGCG ((-)-Epigallocatechin Gallate)	EGCG ((-)-Epigallocatechin Gallate) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.	Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694 Cell Rep, 2025, 44(6):115799 Front Pharmacol, 2024, 15:1403424
S3273	Hypericin	Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. This compound has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).	Eur J Pharmacol, 2021, 900:174071