PKC Activators

Cat.No.	Product Name	Information	Product Use Citations
S7791	PMA chemical (Phorbol 12-myristate 13-acetate)	PMA (Phorbol 12-myristate 13-acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.	Protein Cell, 2025, pwaf020 Nat Commun, 2025, 16(1):8054 Cancer Commun (Lond), 2025, 10.1002/cac2.70036
S9101	Ingenol	Ingenol, a plant-derived diterpenoid, is a weak PKC activator and possesses important anticancer activity.	Scientific Reports, 2020, 13124 Sci Rep, 2020, 10(1):13124
S3289	Daphnoretin	Daphnoretin (Dephnoretin, Thymelol), a biologically active compound isolated from Wikstroemia indica C.A. Mey., is a protein kinase C (PKC) activator. This compound inhibits the proliferation, invasion, and migration of tumor cells and promote its apoptosis by regulating the activity of Akt signal pathway.
S3819	Decursinol angelate	Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.
E5794	Ionomycin calcium	Ionomycin calcium (SQ23377 calcium) is a potent and selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. It is highly specific for divalent cations (Ca>Mg>Sr=Ba) and also promotes T cell activation and proliferation by inducing phosphoinositide hydrolysis and protein kinase C (PKC) activation, leading to IL-2 production and IL-2R expression.
S7074	Ionomycin	Ionomycin (SQ23377) is a potent and selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. It induces the activation of protein kinase C (PKC) and promotes apoptosis.	Protein Cell, 2025, pwaf020 Nat Commun, 2025, 16(1):8054 Cancer Commun (Lond), 2025, 10.1002/cac2.70036