Home DNA Damage/DNA Repair Nucleoside Analog/Antimetabolite

Nucleoside Analog/Antimetabolite Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S1209 5-Fluorouracil (5-FU) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Nature, 2025, 10.1038/s41586-025-08974-4
Cancer Cell, 2025, S1535-6108(25)00223-5
Cell Stem Cell, 2025, S1934-5909(25)00265-6
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S1200 Decitabine Decitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
Cancer Cell, 2025, S1535-6108(25)00223-5
Nat Commun, 2025, 16(1):4451
Cell Rep Med, 2025, S2666-3791(25)00102-8
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S1491 Fludarabine Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.
Cell Mol Immunol, 2025, 22(11):1478-1490
J Immunother Cancer, 2025, 13(7)e010926
Cell Rep, 2025, 44(4):115559
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S1149 Gemcitabine Hydrochloride Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy.
Cancer Cell, 2025, S1535-6108(25)00271-5
Nat Cell Biol, 2025, 27(6):1021-1034
Trends Biotechnol, 2025, S0167-7799(25)00406-8
Verified customer review of Gemcitabine Hydrochloride
S1648 Cytarabine Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.
Nat Commun, 2025, 16(1):4133
Acta Pharm Sin B, 2025, 15(10):5277-5293
Cell Death Dis, 2025, 16(1):601
Verified customer review of Cytarabine
S1807 Acyclovir (Aciclovir) Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses, and it induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
Int J Mol Sci, 2025, 26(15)7185
Virol Sin, 2025, S1995-820X(25)00102-6
Nat Commun, 2024, 15(1):9461
Verified customer review of Acyclovir (Aciclovir)