Home DNA Damage/DNA Repair Nucleoside Analog/Antimetabolite

Nucleoside Analog/Antimetabolite Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S1209 5-Fluorouracil (5-FU) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Adv Sci (Weinh), 2026, 13(19):e11406
Research (Wash D C), 2026, 9:1108
Int J Biol Macromol, 2026, 345:150612
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S1200 Decitabine Decitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
Nucleic Acids Res, 2026, 54(4)gkag089
Sci Rep, 2026, 16(1)14560
Cancer Res Commun, 2026, 6(3):648-656
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S1491 Fludarabine Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.
EMBO J, 2026, 45(9):3056-3072
Neurosci Lett, 2026, 875:138543
Cell Mol Immunol, 2025, 22(11):1478-1490
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S1149 Gemcitabine Hydrochloride Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy.
Oncol Res, 2026, 34(3):12
Cancer Cell, 2025, S1535-6108(25)00271-5
Nat Cell Biol, 2025, 27(6):1021-1034
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S1648 Cytarabine Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.
Molecular Cancer Therapeutics, October 05, 2015, 2249–2259
bioRxiv, March 04, 2025, nan
Cancers, June 08, 2023, 3112
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S1807 Acyclovir (Aciclovir) Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses, and it induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
PeerJ, 2026, 14:e20719
Int J Mol Sci, 2025, 26(15)7185
Virol Sin, 2025, S1995-820X(25)00102-6
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