Home Metabolism Lipoxygenase

Lipoxygenase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
E2671 SR 2640 hydrochloride SR2640 hydrochloride is a potent and selective competitive leukotriene D4/E4 antagonist.
S0759 FPL 62064 FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. This compound has potent anti-inflammatory activity.
S3387 ML351 ML351 is a selective inhibitor of 15-Lipoxygenase-1 (15-LOX-1 or 12/15-LOX) with IC50 of 200 nM.
E0335 4-MMPB 4-MMPB, a selective inhibitor of 15-lipoxygenase (15-LO) with an IC50 of 18 μM, shows IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively.
S5122 Abietic Acid Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.
E0320 Atuliflapon (AZD5718) Atuliflapon (AZD5718) is an oral inhibitor of (FLAP) 5-lipoxygenase activating protein with an IC50 of 2.0 nM. It has the potential to treat coronary artery disease.
E4977 Zileuton sodium Zileuton sodium (A 64077 sodium) is a potent, selective, and specific inhibitor of 5-lipoxygenase, exhibiting inflammatory activities. This compound prevents polyp formation efficiently by reducing tumor-associated and systemic inflammation in in vivo models. It also acts as a potential chemo-preventive agent in patients that are at high risk of developing colon cancer.
S6228 Indole-2-carboxylic acid Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation.
S8011 U-73122 U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN. U73122 potently inhibits human 5-lipoxygenase (5-LO).
EMBO Rep, 2025, 10.1038/s44319-025-00444-2
Front Immunol, 2025, 16:1491928
Cancer Cell Int, 2025, 25(1):408
Verified customer review of U-73122
S2277 Caffeic Acid Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).
Molecules, 2021, 26(5)1210
J Nutr Biochem, 2015, 26(11):1379-84
Sci Rep, 2015, 5:12580
Verified customer review of Caffeic Acid
S3168 cis-Resveratrol cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
S5520 Phenidone Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
E0226 Chebulagic acid

Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. This compound shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. It also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.
S3255 Pectolinarigenin Pectolinarigenin, an active anti-inflammatory ingredient in Cirsium chanroenicum, is a dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).
S3283 Marmesin Marmesin (S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin) is a natural coumarin with COX-2 and 5-LOX dual inhibitory activity.