Lipoxygenase Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S9421	Demethylnobiletin	Demethylnobiletin (5-Demethylnobiletin) is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers. This compound is a direct inhibitor of 5-LOX with IC50 of 0.1 μM, without affecting the expression of COX-2. It has anti-inflammatory activity, inhibits leukotriene B 4(LTB4) formation in rat neutrophils and elastase release in human neutrophils with IC50 of 0.35 μM.	Front Oncol, 2023, 13:1143664
S4711	Esculetin	Esculetin (Cichorigenin, Aesculetin) is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).	Cancer Lett, 2021, S0304-3835(21)00436-5 Cancer Letters, 2021, 308-321
E2671	SR 2640 hydrochloride	SR2640 hydrochloride is a potent and selective competitive leukotriene D4/E4 antagonist.
S0759	FPL 62064	FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. This compound has potent anti-inflammatory activity.
E0335	4-MMPB	4-MMPB, a selective inhibitor of 15-lipoxygenase (15-LO) with an IC50 of 18 μM, shows IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively.
S5122	Abietic Acid	Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.
E0320	Atuliflapon (AZD5718)	Atuliflapon (AZD5718) is an oral inhibitor of (FLAP) 5-lipoxygenase activating protein with an IC50 of 2.0 nM. It has the potential to treat coronary artery disease.
S6228	Indole-2-carboxylic acid	Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation.
S8011	U-73122	U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca²⁺ increases in platelets and PMN. U73122 potently inhibits human 5-lipoxygenase (5-LO).	EMBO Rep, 2025, 10.1038/s44319-025-00444-2 Front Immunol, 2025, 16:1491928 Cancer Cell Int, 2025, 25(1):408
S2277	Caffeic Acid	Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).	Molecules, 2021, 26(5)1210 J Nutr Biochem, 2015, 26(11):1379-84 Sci Rep, 2015, 5:12580
S3168	cis-Resveratrol	cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.	J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
S5520	Phenidone	Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
E0226	Chebulagic acid	Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. This compound shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. It also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.
S3255	Pectolinarigenin	Pectolinarigenin, an active anti-inflammatory ingredient in Cirsium chanroenicum, is a dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).
S3283	Marmesin	Marmesin (S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin) is a natural coumarin with COX-2 and 5-LOX dual inhibitory activity.