IRE1 Inhibitors

Featured Inhibitors
Inhibitors (11)
Activator (1)

Cat.No.	Product Name	Information	Product Use Citations
S7781	Sunitinib (SU-11248)	Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.	Cancer Cell, 2025, 43(4):776-796.e14 Mol Cancer, 2025, 24(1):179 J Exp Clin Cancer Res, 2025, 44(1):290
S1042	Sunitinib (SU11248) Malate	Sunitinib malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.	Nat Commun, 2025, 16(1):7853 CNS Neurosci Ther, 2025, 31(12):e70696 Sci Rep, 2025, 15(1):35889
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Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7781

Sunitinib (SU-11248)

Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.

Cancer Cell, 2025, 43(4):776-796.e14

Mol Cancer, 2025, 24(1):179

J Exp Clin Cancer Res, 2025, 44(1):290

Verified customer review of Sunitinib (SU-11248)

S1042

Sunitinib (SU11248) Malate

Sunitinib malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.

Nat Commun, 2025, 16(1):7853

CNS Neurosci Ther, 2025, 31(12):e70696

Sci Rep, 2025, 15(1):35889

Verified customer review of Sunitinib (SU11248) Malate

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