IRE1 Activator

Cat.No. Product Name Information Product Use Citations Product Validations
S9797 IXA4 IXA4, a highly selective, non-toxic IRE1/XBP1s activator, activates IRE1/XBP1s signaling without globally activating the unfolded protein response (UPR) or other stress-responsive signaling pathways, and reduces secretion of amyloid precursor protein (APP) through IRE1 activation, preventing APP-associated mitochondrial dysfunction.
Cell Regen, 2025, 14(1):18
bioRxiv, 2025, 2025.09.07.674755
EMBO J, 2023, e113118.