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HSP Modulators

Cat.No. Product Name Information Product Use Citations Product Validations
S1052 Elesclomol (STA-4783) Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand and inhibits FDX1-mediated Fe-S cluster biosynthesis.Elesclomol (STA-4783) is a potent copper ionophore and can be used in the research of copper-dependent cell death (cuproptosis).
Nat Commun, 2025, 16(1):212
Cell Prolif, 2025, e70101.
J Transl Med, 2025, 23(1):127
Verified customer review of Elesclomol (STA-4783)
S8299 HA15 HA15 is a molecule that targets specifically HSPA5 (Heat shock 70kDa protein 5) also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). This compound displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
Clin Transl Med, 2024, 14(2):e1567
PLoS Pathog, 2024, 20(10):e1012660
Cancer Res, 2023, 83(16):2750-2762
Verified customer review of HA15
S8305 TRC051384 TRC051384 is an inducer of heat shock protein 70 (HSP70) and potent anti-inflammatory agent.
Exp Mol Med, 2022, 10.1038/s12276-022-00745-9
Front Cell Dev Biol, 2021, 9:796974
Mol Cell Biochem, 2021, 10.1007/s11010-021-04052-1
E0701 Cucurbitacin D Cucurbitacin D is an active component in Cucurbita texana, disrupts maturation of HSP90 and interactions between Hsp90 and two co-chaperones, Cdc37 and p23.