HSP Activators

Cat.No.	Product Name	Information	Product Use Citations
S0294	HSF1A	HSF1A is a cell-permeable heat shock transcription factor 1 (HSF1) activator. This compound protects cells from stress-induced apoptosis, binds TRiC subunits and inhibits TRiC activity without perturbation of ATP hydrolysis.
S6568	ML346	ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases.
E0362	BiP Inducer X (BIX)	BIX (BiP Inducer X) is a selective GRP78 (BiP, HSPA5) inducer. It induces BiP only, in a dose-dependent manner, without induction of other molecules involved in the ER stress response.
S1238	Tamoxifen	Tamoxifen is an orally active, selective estrogen receptor modulator (SERM) which exhibits both estrogenic agonist and antagonist effects. It blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity.	Cell Discov, 2025, 11(1):89 Nat Genet, 2025, 57(9):2192-2202 Cell Metab, 2025, 37(8):1715-1731.e11
S1972	Tamoxifen Citrate	Tamoxifen Citrate is a selective estrogen receptor modulator (SERM). This compound is also a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. It induces apoptosis and autophagy.	bioRxiv, 2025, 2025.07.21.666025 bioRxiv, 2024, 2023.05.10.540211 EMBO Rep, 2023, 24(5):e55835
S0279	Dimethylenastron	Dimethylenastron is a potent, specific and reversible inhibitor of kinesin Eg5 (kinesin-5/kinesin spindle protein, KSP) with IC50 of 200 nM. This compound induces mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells.	EMBO Rep, 2023, e57234.